Kubva muna Zvita 2019, COVID-19 yakakonzerwa neyakakomba Acute Respiratory Syndrome (SARS) yakapararira pasirese.Hutachiona hunokonzeresa COVID-19 ndiSARS-COV-2, hutachiona hweRNA hunosanganisira mhuri yekoronaviruses.β coronaviruses ane denderedzwa kana ovha muchimiro, 60-120 nm muhupamhi, uye kazhinji pleomorphic.Nekuti iyo Envelopu yehutachiona ine convex chimiro chinogona kutenderera kumativi ese uye inoita senge corolla, inonzi coronavirus.Iine capsule, uye S (Spike protein), M (Membrane protein), M (matrix protein) uye E (Envelope protein) inoparadzirwa pane capsule.Iyo envelopu ine RNA inosunga kuN (Nucleocapsid protein).Iyo S protein yeSARS-COV-2ine S1 uye S2 subunits.Iyo receptor-binding domain (RBD) yeS1 subunit induces SARS-COV-2 utachiona nekusunga kune angiotensin inoshandura enzyme 2 (ACE2) pane cell surface.
Sars-cov-2 inogona kutapuriranwa kubva kumunhu ichienda kumunhu uye inotapuriranwa zvakanyanya kupfuura sarS-COV, iyo yakatanga muna 2003. Inonyanya kutapuriranwa nemadonhwe ekufema uye kubata kwevanhu pedyo, uye inogona kutapurirwa neaerosol kana iripo munzvimbo. ine airtight yakanaka kwenguva yakareba.Vanhu vanowanzo batwa nechirwere, uye nguva yekudyara izuva 1 kusvika ku14, kazhinji mazuva matatu kusvika matatu.Mushure mekutapukirwa neinoveli coronavirus, zvinyoro nyoro zveCCIDID-19 zvinokura zviratidzo zvakanyanya zvefivha uye chikosoro chakaoma.COVID-19 inotapukira zvakanyanya uye inotapukira zvakanyanya mumatanho asymptomatic ehutachiona.Sars-cov-2 hutachiona hwehutachiona hunogona kukonzera fivha, kuoma kukosora, kuneta uye zvimwe zviratidzo.Varwere vakanyanya vanowanzoita dyspnea uye / kana hypoxemia 1 vhiki mushure mekutanga, uye varwere vakaoma vanogona kutungamirira kune acute breathing distress syndrome, coagulopathy uye kukanganisa kwenhengo dzakawanda.
Nekuti sarS-COV-2 inotapurirana zvakanyanya uye inouraya, nekukurumidza, kwakaringana uye nyore nzira dzekuongorora dzekuonekwa kweSARS-COV-2 uye kuparadzaniswa nevanhu vane hutachiona (kusanganisira asymptomatic vane hutachiona) ndiyo kiyi yekuona kwakabva hutachiona, kudzivirira kutapurirana kwechirwere ichi nekudzivirira nekudzora denda.
POCT, inozivikanwawo se tekinoroji yekuona padivi pemubhedha kana tekinoroji yekuona-nguva chaiyo, imhando yenzira yekuona iyo inoitwa panzvimbo yesampling uye inogona kukurumidza kuwana mibairo yekuona nekushandisa inotakurika yekuongorora zviridzwa.Panyaya yekuonekwa kwepathogen, POCT ine mabhenefiti ekukurumidza kuona nekukurumidza uye hapana saiti inorambidzwa kana ichienzaniswa nemaitiro ekuona echinyakare.POCT haingokurumidze chete kuonekwa kweCCIDID-19, asi zvakare kudzivirira kusangana pakati pevashandi vekuona nevarwere uye kuderedza njodzi yekutapukirwa.Parizvino,Kuongororwa kweCOVID-19nzvimbo muChina zvakanyanya zvipatara uye yechitatu-bato rekuongorora nzvimbo, uye vashandi vanoedza vanofanirwa kutora samples zvakananga pamberi pevanhu kuti vaongororwe.Zvisinei nematanho ekudzivirira, kutora sample kubva kumurwere kunowedzera njodzi yekutapukirwa kumunhu anoiedza.Naizvozvo, kambani yedu yakanyatso gadzira kit yekuti vanhu vaedze kumba, ine zvakanakira kuona nekukurumidza, kushanda kuri nyore, uye kuonekwa kumba, chiteshi nedzimwe nzvimbo pasina biosafety kuchengetedza mamiriro.
Tekinoroji huru inoshandiswa ndeye immunochromatography tekinoroji, inozivikanwawo seLateral Flow assay (LFA), inova nzira yekukurumidza yekuona inotungamirwa necapillary action.Seye tekinoroji yekuona nekukurumidza, ine mashandiro ari nyore, nguva pfupi yekuita uye mhedzisiro yakagadzikana.Iyo inomiririra ndeye colloidal gold immunochromatography paper (GLFA), iyo inowanzobatanidza sampuli pad, bond pad, nitrocellulose (NC) firimu uye mvura inopinza pad, nezvimwewo. Bond pad inogadziriswa ne antibody modified gold nanoparticles (AuNPs), uye NC. firimu rinogadziriswa nekutora antibody.Mushure mekunge sampu yawedzerwa kune sampuli pad, inoyerera nepakati pedhi rekubatanidza uye NC firimu zvakateerana pasi pechiito che capillary, uye pakupedzisira inosvika padhi inonyudza.Kana sample ichipinda nepapedhi yekusungirira, chinhu chichayerwa mumucherechedzo chinobatana negold label antibody;Sample payaiyerera nepakati peNC membrane, sample yaizoedzwa yakatorwa uye yakagadziriswa neantibody yakabatwa, uye mabhendi matsvuku akaonekwa paNC membrane nekuda kwekuunganidzwa kwegoridhe nanoparticles.Kukurumidza kutariswa kwemhando yeSARS-COV-2 inogona kuwanikwa nekutarisa mabhendi matsvuku munzvimbo yekuona.Iyo kit yeiyi nzira iri nyore kutengeserana uye yakamisikidzwa, iri nyore kushanda uye nekukurumidza kupindura.Yakakodzera kuongorora huwandu hwevanhu uye inoshandiswa zvakanyanya mukuonekwa kweiyo novel Coronavirus.
Novel coronavirus zvirwereidambudziko rakakura rakatarisana nenyika.Kukurumidza kuongororwa uye kurapwa panguva yakakodzera ndiyo kiyi yekukunda muhondo.Mukutarisana nehutachiona hwepamusoro uye nhamba huru yevanhu vane utachiona, zvakakosha zvikuru kukudziridza maitirwo akarurama uye akakurumidza kuona.Zvinozivikanwa kuti pakati pezvinowanzo shandiswa samples, alveolar lavage fluid ine yakanyanya kunaka mwero pakati pe pharyngeal swabs, mate, sputum uye alveolar lavage fluid.Parizvino, bvunzo yakajairika ndeyekutora samples kubva kune vanofungidzirwa varwere vane huro swabs kubva kumusoro pharynx, kwete rezasi rekufema turakiti, uko hutachiona hunogona kupinda nyore.Utachiona hunogonawo kuonekwa muropa, weti, uye tsvina, asi haisi iyo nzvimbo huru yehutachiona, saka huwandu hwehutachiona hushoma uye haugoni kushandiswa sechikonzero chekuonekwa.Pamusoro pezvo, sezvo RNA isina kugadzikana uye iri nyore kudzikisira, kurapwa kwakanaka uye kubviswa kwemasampuli mushure mekuunganidza zvinhu zvakare.
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Nguva yekutumira: May-20-2022